7 Mushroom Immunity Blend | Unpacking The Research
The Basics
This ultra high quality 7-mushroom blend combines historically revered medicinal mushrooms: Lion's Mane, Reishi, Chaga, Cordyceps, Shiitake, Turkey Tail, and Tremella. With focus on extracting the immune-boosting polysaccharides from each mushroom, we’ve achieved a potent 30% polysaccharide content. Creating a rich and concentrated composition of unique functional compounds, the emphasis lies on their collective power to bolster immunity. This blend represents a scientifically backed approach to enhancing immune function and promoting overall health through the targeted utilization of a natural variety of polysaccharides including β, PSP and PSK. Please browse the heavily researched properties and potential benefits of each mushroom below. However despite the promising findings, research is ongoing and results have not yet been deemed conclusive by the EFSA, please form your own opinion of the scientific conclusions below.
Ingredients
Lions Mane
Lions Mane Research
Improved Cognitive Function
Study 1: According to a 2019 study, the oral intake of H. erinaceus significantly improved cognitive functions and prevented from the deterioration.
Source: Improvement of cognitive functions by oral intake of Hericium erinaceus (2019)
Study 2: Another research effort suggests that some of the bioactive compounds extracted from H. erinaceus have been shown to recover, or at least ameliorate, a wide range of pathological brain conditions such as Alzheimer's disease, depression, Parkinson's disease, and spinal cord injury.
Source: Hericium erinaceus in Neurodegenerative Diseases (2023)
Enhanced Nerve Growth and Repair
Study 1: This study shows that the aqueous extract of H. erinaceus contained neuroactive compounds which induced NGF-synthesis and promoted neurite outgrowth in NG108-15 cells.
Source: Neurotrophic properties of the Lion's mane medicinal mushroom(2013)
Study 2: Another research effort demonstrated that H. erinaceus (Lion's Mane) extract enhances Nerve growth factor gene expression and protein secretion, which in turn promotes neurite outgrowth, a fundamental process for nerve regeneration and plasticity.
Source: Nerve growth factor-inducing activity of Hericium erinaceus (Lions Mane) (2008)
Study 3: Specific parts of Lion's Mane mushroom extracts, especially the hercinones, significantly increase axonal length and the number of neurites, indicating a strong effect on nerve growth.
Source: Lions Mane derivatives activates a pan-neurotrophic pathway in central hippocampal neurons (2023)
Study 4: Two classes of terpenoid compounds, hericenones and erinacines, from fruiting bodies and cultured mycelia, respectively, have been found to stimulate nerve growth factor (NGF) synthesis.
Source: Hericium erinaceus [Lions Mane], an amazing medicinal mushroom (2015)
Reduced Anxiety and Depression
There are indications that Lion's Mane Mushroom could potentially be used as a treatment for depression. A 4-week intake of this mushroom extract has been found to significantly reduce depression and anxiety symptoms in adults.
Source: Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake (2010)
Boosted Immune System
Lion's Mane Mushroom extract has been found to have antioxidant and immunomodulatory (immune system-regulating) effects in animal models. It has also been shown to enhance immune function in mice.
Source: Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus[Lions Mane] through Regulating the Gut Microbiota (2017)
What Makes Our Lions Mane Superior?
Dual Extraction: Maximizing the Benefits
Unlike many competitors who only use one extraction method, we use a dual extraction process for our Lion's Mane. This method combines hot water and alcohol extraction to ensure that we capture the full spectrum of functional compounds from the Lion's Mane mushroom. Hot water extraction is excellent for pulling immune-boosting polysaccharides, while alcohol extraction helps us obtain potential nerve growth factors, such as hericinones. By combining these two methods, we can ensure that our Lion's Mane supplement offers the complete range of benefits this remarkable mushroom has to offer.
Fruiting Body Extraction: The Purest Part
We believe in offering the best to our customers. That's why we only extract from the fruiting body of the Lion's Mane mushroom. This part is considered the most potent and purest part of the mushroom, unlike the cheaper mycelium used by some other brands.
100% Organic: Free from Harmful Chemicals
At Andïnn Organics, we are committed to your health and wellbeing. That's why our Lion's Mane is 100% organic. This means it's free from any potentially harmful chemicals found in pesticides or fertilisers. We ensure that what you receive is pure, potent, and beneficial.
Superior Quality: 20% Beta-polysaccharides and 1% Hericinones
Quality matters, and we don't compromise on ours. Our Lion's Mane contains a robust 20% beta-polysaccharides and a respectable 1% hericinones. These levels are indicative of a high-quality Lion's Mane supplement, making ours a superior choice.
Reishi
Reishi Research
Boosting the immune system
Source: https://www.nature.com/articles/s41598-023-41557-9
Study 2: A 2018 review of 14 clinical trials found that Reishi mushroom extract may have a beneficial effect on the immune system in cancer patients.
Source: https://pubmed.ncbi.nlm.nih.gov/30410443/
Study 3: A 3-month study found that two fungal supplements, Ganoderma lucidum and Cordyceps sinensis, helped 7 amateur cyclists manage stress hormones and fight oxidative stress, potentially aiding their performance.
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995149/
Improving sleep quality
Source: https://www.nature.com/articles/s41598-021-92913-6
Study 2: Three-day administration of Reishi Extract significantly increased total sleep time and non-rapid eye movement (NREM) sleep time at a dose of 80 mg/kg (i.g.) without influencing slow-wave sleep or REM sleep in freely moving rats.
Source: https://www.sciencedirect.com/science/article/abs/pii/S0378874111008981
Study 3: “Ganoderma (or reishi) exerts an anti-insomnia effect via complex central-peripheral multi-level interaction networks.”
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555286/
Reducing Fatigue
Source: https://pubmed.ncbi.nlm.nih.gov/15857210/
Protecting against cancer
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353236/
Study 2: “Our results indicate that Ganoderma has a broad-spectrum application for the treatment of cancer through the regulation of the immune system.”
Source: https://pubmed.ncbi.nlm.nih.gov/30410443/
Reducing inflammation
Source: https://www.sciencedirect.com/science/article/abs/pii/S027869152100106X
What Makes Our Reishi Superior?
Organic Certification
Our Reishi extract isn't just any mushroom supplement. It's a premium quality extract that's both USDA and EU certified organic. This means our Reishi offering is entirely free from unnatural fertilisers and pesticides.
Powerful Extract Ratio
Our Reishi extract boasts a powerful 10:1 strength. This means that it takes at least 10 grams of fresh Reishi mushroom to produce just 1 gram of our extract powder. .
Dual Extraction Technique
We use a specialized dual extraction method using both hot water and alcohol extraction to procure the full spectrum of functional compounds from the Reishi mushroom. This unique process allows us to maintain a remarkable 20% polysaccharide content and 5% triterpenoid content in our extract, offering a robust profile of beneficial compounds.
Rich in Functional Compounds
One of the hallmarks of our Reishi extract is its high triterpenoid concentration. At 5%, it's a rare find in the world of health supplements. Triterpenoids are a group of naturally occurring acids known for their potential health benefits. And due to our specialised Duel extraction technique, we also offer a 20% concentration of rich polysaccharides, known for their immunity modulation benefits, amongst others.
Chaga
Chaga Research
Immune-boosting
Study 1: "The results of this study suggest that Chaga mushroom extract may have immune-boosting properties. Further research is needed to confirm these findings and to determine the best way to use Chaga for immune support."
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142110/
Study 2: "In conclusion, all these results suggest that the water extract of Chaga mushroom is a very potent immune modulator that recovers the bone marrow system damaged by chemotherapy"
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774877/
Anti-inflammatory
Study 1: "In response to increasing interest in on the health-promoting effects of chaga (Inonotus obliquus), we have shown that chaga collected in Maine, USA, exhibits significant anti-inflammatory properties"
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268247/
Study 2: "Chaga mushrooms contain a variety of bioactive compounds that have anti-inflammatory properties. For example, Chaga extract has been shown to inhibit the production of inflammatory cytokines, which are proteins that promote inflammation. Chaga extract has also been shown to reduce the activity of COX-2, an enzyme that plays a role in inflammation."
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6142110/
Cell Protection
"Cells pretreated with Chaga extract showed over 40% reduction in DNA fragmentation compared with the positive control (100 micromol H2O2 treatment). Thus, Chaga mushroom treatment affords cellular protection"
Source: https://pubmed.ncbi.nlm.nih.gov/15630179/
Antioxidant Activity
Study 1: "Chaga mushroom polysaccharides (IOPS) have been shown to have a wide range of biological activities, including antioxidant, anti-inflammatory, and immunomodulatory effects. IOPS have been shown to scavenge free radicals and protect cells from oxidative damage."
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124789/
Study 2: "Aqueous extracts of Chaga have been shown to have anti-inflammatory and antioxidant properties. The study found that Chaga extracts obtained by different extraction methods showed different degrees of anti-inflammatory and antioxidant activity."
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9268247/
What Makes Our Chaga Superior?
Dual Extraction Process
Our Chaga is extracted using a dual extraction process, a method that ensures the highest possible concentration of beneficial compounds. This meticulous method allows us to extract both water and alcohol-soluble compounds, providing a potent extract rich in polysaccharides and triterpenoids.
High Concentration of Functional Compounds
Our Chaga boasts a high 30% concentration of polysacaccharides. Polysaccharides are known for their potential to support various bodily functions, although we make no specific health claims in accordance with EFSA policy.
Our Chaga also contains a respectable 1% triterpenoids. Triterpenoids are a type of compound found in certain types of fungi, including Chaga.
Powerful Concentration
We ensure a powerful concentration of our Chaga with an extract ratio of 14:1. This means that for every 14 parts of raw Chaga, we produce one part of concentrated extract. This high concentration ratio ensures you get a potent, high-quality product.
Organic and High Quality
At Andïnn Organics, we hold ourselves to the highest standards. Our Chaga is not only organic, but it is also of high quality all round. We source our Chaga from reputable suppliers, ensuring it is grown and harvested sustainably and ethically.
Cordyceps
Turkey Tail
Turkey Tail Research
Immune System
This study reveals that both the mycelium and the fruiting body of Turkey Tail have the potential to activate different components of the immune system.
“Both aqueous and solid fractions of FS triggered large and dose-dependent increases in immune-activating pro-inflammatory cytokines”
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889544/
Gut Health
A 2013 test-tube study mirrored these results finding a Turkey Tail extract to have modified the gut bacterial composition by increasing the population of beneficial strains of gut bacteria Bifidobacterium and Lactobacillus while reducing potentially harmful bacteria Clostridium and Staphylococcus
Source: https://www.researchgate.net/publication/235717058_Trametes_versicolor_Extract_Modifies_Human_Fecal_Microbiota_Composition_In_vitro
Cancer
**Turkey Tail is not a replacement to convenvtional cancer therapy - However, there is growing evidence it may be beneficial in tandem with conventional therapies including chemo therapy, always consult your doctor before use**
"Preclinical in vitro and in vivo data suggest that PSP[ = Polysaccharopeptide Present In Turkey Tail Mushroom] has immunomodulatory (largely immune stimulisation) effects that may be beneficial, particularly when combined with anticancer treatment."
Source: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592279/
Meta-Analysis Insights: A 2007 meta-analysis included multiple randomized controlled trials (RCTs) totaling 8,009 patients and indicated an Overall Survival (OS) hazard ratio of 0.88, thereby illustrating the potential clinical significance of adding PSK as an adjuvant immunotherapy for patients with gastric cancer. - Simply put, this large study from 2007 showed that adding PSK from Turkey Tail to the usual treatment helped people with gastric cancer live longer.
Source: https://www.cancer.gov/about-cancer/treatment/cam/hp/mushrooms-pdq#_7
What Makes Our Turkey Tail Superior?
Organic Certification
Our Turkey Tail is USDA (United States Department of Agriculture) and EU (European Union) certified organic. This means that our product is free from synthetic additives like pesticides, chemical fertilizers, and dyes. It also ensures that our Turkey Tail is not processed using industrial solvents, irradiation, or genetic engineering, making it a safe and reliable choice.
Powerful Extract Ratio
Our Turkey Tail boasts a potent 12:1 extract ratio. Simply put, it takes 12 grams of fresh Turkey Tail to produce just 1 gram of our extract. This high concentration ensures that you get the most out of each dose, providing a potent, high-quality supplement.
Rich in Functional Compounds
Our Turkey Tail is rich in functional compounds, boasting 30% polysaccharides. These include Polysaccharopeptide (PSP) and Polysaccharide Krestin (PSK), compounds that have been extensively researched for their potential benefits. Our high polysaccharide content makes our Turkey Tail a powerful choice for those seeking a supplement packed with beneficial compounds.
Purity Guaranteed
We believe in delivering products that are pure and unadulterated. Our Turkey Tail is 100% pure, with no additives to dilute its authentic concentration. When you choose our Turkey Tail, you're choosing a product that is as close to its natural state as possible, ensuring you receive all the benefits this amazing mushroom has to offer.
Shiitake
Shiitake Research
Immunity
Study 1: Regular L. edodes consumption (5 or 10 grams of shiitake mushrooms daily for 4 weeks) resulted in improved immunity: it was found that consuming whole dried L. edodes mushrooms led to a boost in the growth and activation of certain immune cells, an increase in protective proteins in saliva, a reduction in inflammation markers in the blood, and a modulation in the production of various immune response proteins, enhancing the overall immune function in healthy young individuals.
Source: Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity (2015)
Study 2: “Polysaccharides derived from L. edodes (Shiitake mushrooms) have been confirmed to exhibit immunomodulatory properties by modulating both innate and adaptive immune responses”
Source: Immunomodulatory Properties of Polysaccharides from Lentinula edodes (2022)
Cardiovascular Health
Study 1: The dietary mushrooms decreased the blood pressure. The plasma free cholesterol level decreased in Shiitake-fed animals. Shiitake feeding resulted in a decrease in VLDL- and HDL-cholesterol whereas Maitake feeding caused a decrease in VLDL-cholesterol only. The results suggest that dietary mushrooms prevent blood pressure increase in hypertension.
Source: Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids (1987)
Study 2: The extracts were found to have strong antioxidant and anti-inflammatory properties, and they were able to inhibit the oxidation of low density lipoprotein (LDL) and the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR), a key enzyme in cholesterol synthesis. These findings suggest that shiitake mushrooms may be beneficial for cardiovascular health.
Source: Lentinula edodes (shiitake mushroom): An assessment of in vitro anti-atherosclerotic bio-functionality (2018)
What Makes Our Shiitake Superior?
Uncompromising Quality and Purity:
At Andïnn Organics, we believe in providing only the best for our customers, and our shiitake mushroom supplement is no exception. Unlike other products on the market, our shiitake is 100% pure, with no fillers or additives. We take pride in ensuring that what you get is nothing but the pure, organic goodness of shiitake mushrooms, straight from nature.
High Potency for Maximum Benefit:
Our shiitake mushrooms are not just organic, but they also boast a potent extract ratio. For every 1 gram of our extract, we use 12 grams of fresh mushrooms. This means that you get the maximum benefit from each serving, making our shiitake superior in terms of potency and effectiveness.
Rich in Polysaccharides:
Our shiitake supplement is high in polysaccharides - a type of carbohydrate that is known for its potential benefits. We ensure that our shiitake extract contains 40% polysaccharides, a concentration that is hard to find in other products. This high polysaccharide content further enhances the quality and potential benefits of our shiitake supplement.
Organic and Responsible Sourcing:
As the name suggests, Andïnn Organics is all about organic products. Our shiitake mushrooms are organically grown, ensuring that they are free from harmful chemicals and pesticides. We believe in responsible sourcing and only work with growers who share our commitment to organic farming and sustainable practices.